The physostigmine controversy
نویسندگان
چکیده
منابع مشابه
Physostigmine as an Antidote
Introduction: Rapid treatment of patients with anticholinergic toxicity in the Ernergcncy Department (ED) has remained problematic for many years. These patients are often agitated. uncooperative, and unable to provide a clear history. Physostigmine is a specific antidote for anticholinergic toxicity. yet its popularity has waned due to controversy surrounding its potential central nervo~is sys...
متن کاملAtrial fibrillation following physostigmine.
The side effects of physostigmine, a tertiary amine anticholinesterase agent commonly used to treat postanaesthetic depression caused by a large number of drugs, are thought to be fairly mild. A case is reported in which atrial fibrillation followed a total dose of 2 mg of this drug to a patient who was slow in recovering from a general anaesthetic. The arrhythmia was self-limiting and required...
متن کاملRole of the adrenergic system in physostigmine-induced yawning
In this study the effect of adrenergic receptor agonists and antagonists on physostigmine induced yawning was investigated. Intraperitoneal injection of different doses of physostigmine (0.03, 0.05, 0.1 and 0.2 mg/kg) caused yawning in white rats. The greatest response was seen at a dose of 0.2 mg/kg physostigmine. Phenylephrine, an α1 agonist, and clonidine, an α2 agonist, led to a decrease in...
متن کاملNEUROGENIC HYPERTENSION: REPORT OF FIVE CASES TO HIGHLIGHT THE CONTROVERSY
The entity of "neurogenic hypertension" is defined as arterial hypertension caused explicitly by derangement of the intricate network of the central nervous system. Among 193 cases of cranial rhizopathies operated on between 1984 and 1995 at this center, 5 cases of established arterial hypertension with concomitant rhizopathies also underwent ventrolateral medullary decompression. The elev...
متن کاملPhysostigmine-induced cerebral protection against hypoxia.
Physostigmine, at 0.1, 0.2 and 0.3 mg/kg, was tested for effect on the survival of mice exposed to 5% O2-95% N2. Some treated animals survived for one hour under the hypoxic atmosphere (2 out of 14 at 0.1 mg/kg and 8 out of 28 at 0.2 and 0.3 mg/kg), an event never observed in untreated controls. The physostigmine-treated animals that died before the hour showed a dose-related increase in surviv...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1989
ISSN: 0014-5793
DOI: 10.1016/0014-5793(89)80911-1